Reversal of indoleamine 2,3-dioxygenase–mediated cancer immune suppression by systemic kynurenine de...
Reversal of indoleamine 2,3-dioxygenase–mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme
About this item
Full title
Author / Creator
Triplett, Todd A , Garrison, Kendra C , Marshall, Nicholas , Donkor, Moses , Blazeck, John , Lamb, Candice , Qerqez, Ahlam , Dekker, Joseph D , Tanno, Yuri , Lu, Wei-Cheng , Karamitros, Christos S , Ford, Kyle , Tan, Bing , Zhang, Xiaoyan M , McGovern, Karen , Coma, Silvia , Kumada, Yoichi , Yamany, Mena S , Sentandreu, Enrique , Fromm, George , Tiziani, Stefano , Schreiber, Taylor H , Manfredi, Mark , Ehrlich, Lauren I R , Stone, Everett and Georgiou, George
Publisher
New York: Springer New York
Journal title
Language
English
Formats
Publication information
Publisher
New York: Springer New York
Subjects
More information
Scope and Contents
Contents
Therapeutic inhibition of the immunosuppressive IDO1–TDO pathway in tumors is achieved
in vivo
with an enzyme.
Increased tryptophan (Trp) catabolism in the tumor microenvironment (TME) can mediate immune suppression by upregulation of interferon (IFN)-γ-inducible indoleamine 2,3-dioxygenase (IDO1) and/or ectopic expression of the predomina...
Alternative Titles
Full title
Reversal of indoleamine 2,3-dioxygenase–mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme
Authors, Artists and Contributors
Author / Creator
Garrison, Kendra C
Marshall, Nicholas
Donkor, Moses
Blazeck, John
Lamb, Candice
Qerqez, Ahlam
Dekker, Joseph D
Tanno, Yuri
Lu, Wei-Cheng
Karamitros, Christos S
Ford, Kyle
Tan, Bing
Zhang, Xiaoyan M
McGovern, Karen
Coma, Silvia
Kumada, Yoichi
Yamany, Mena S
Sentandreu, Enrique
Fromm, George
Tiziani, Stefano
Schreiber, Taylor H
Manfredi, Mark
Ehrlich, Lauren I R
Stone, Everett
Georgiou, George
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2070800654
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2070800654
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.4180
