Optimizing orthogonality
Optimizing orthogonality
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
A new pyrrolysyl-tRNA synthetase/
Pyl
tRNA (PylRS/
Pyl
tRNA) pair that is mutually orthogonal to existing PylRS/
Pyl
tRNA pairs has now been discovered and optimized. This system could enable the site-specific incorporation of a greater number of distinct non-canonical amino acids into a protein.
Alternative Titles
Full title
Optimizing orthogonality
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Record Identifier
TN_cdi_proquest_miscellaneous_2073321170
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2073321170
Other Identifiers
ISSN
1755-4330,1755-4349
E-ISSN
1755-4349
DOI
10.1038/s41557-018-0115-7