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UCP2 is highly expressed in pancreatic a-cells and influences secretion and survival

UCP2 is highly expressed in pancreatic a-cells and influences secretion and survival

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_20890652

UCP2 is highly expressed in pancreatic a-cells and influences secretion and survival

About this item

Full title

UCP2 is highly expressed in pancreatic a-cells and influences secretion and survival

Publisher

Washington: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (33), p.12057-12062

Language

English

Formats

Publication information

Publisher

Washington: National Academy of Sciences

More information

Scope and Contents

Contents

In pancreatic β-cells, uncoupling protein 2 (UCP2) influences mitochondrial oxidative phosphorylation and insulin secretion. Here, we show that α-cells express significantly higher levels of UCP2 than do β-cells. Greater mitochondrial UCP2-related uncoupling was observed in α-cells compared with β-cells and was accompanied by a lower oxidative phos...

Alternative Titles

Full title

UCP2 is highly expressed in pancreatic a-cells and influences secretion and survival

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_20890652

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_20890652

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

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