STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells
STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Immunosuppressive myeloid-derived suppressor cells (MDSC) subvert antitumor immunity and limit the efficacy of chimeric antigen receptor T cells (CAR-T). Previously, we reported that the GM-CSF/JAK2/STAT3 axis drives liver-associated MDSC (L-MDSC) proliferation and blockade of this axis rescued antitumor immunity. We extended these findings in our...
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STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells
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TN_cdi_proquest_miscellaneous_2097588824
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2097588824
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-018-0449-z
