A[beta]42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
A[beta]42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
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New York: Springer Nature B.V
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English
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New York: Springer Nature B.V
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We have generated a novel transgenic mouse model on a C57BL/6J genetic background that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated presenilin 1 under the control of a neuron-specific Thy1 promoter element (APPPS1 mice). Cerebral amyloidosis starts at 6-8 weeks and the ratio of human amyloid (A)beta42 to Abeta40 is 1....
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A[beta]42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
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TN_cdi_proquest_miscellaneous_21056111
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_21056111
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ISSN
1469-221X
E-ISSN
1469-3178,1469-221X
DOI
10.1038/sj.embor.7400784
