Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in...
Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells
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Author / Creator
Hasegawa, H , Yamada, Y , Iha, H , Tsukasaki, K , Nagai, K , Atogami, S , Sugahara, K , Tsuruda, K , Ishizaki, A and Kamihira, S
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
It has been reported that the induction of cellular senescence through p53 activation is an effective strategy in tumor regression. Unfortunately, however, tumors including adult T-cell leukemia/lymphoma (ATL) have disadvantages such as p53 mutations and a lack of
p16
INK4a
and/or
p14
ARF
. In this study we characterized Nutlin-3a...
Alternative Titles
Full title
Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells
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TN_cdi_proquest_miscellaneous_21226046
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_21226046
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2009.171
