Mitochondrial apoptosis is induced by Alkoxy phenyl-1-propanone derivatives through PP2A-mediated de...
Mitochondrial apoptosis is induced by Alkoxy phenyl-1-propanone derivatives through PP2A-mediated dephosphorylation of Bad and Foxo3A in CLL
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Pagano, Mario Angelo , Tibaldi, Elena , Molino, Pierfrancesco , Frezzato, Federica , Trimarco, Valentina , Facco, Monica , Zagotto, Giuseppe , Ribaudo, Giovanni , Leanza, Luigi , Peruzzo, Roberta , Szabò, Ildikò , Visentin, Andrea , Frasson, Martina , Semenzato, Gianpietro , Trentin, Livio and Brunati, Anna Maria
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Protein phosphatase 2 A (PP2A) is a tumour suppressor whose strong inhibition underlies the phosphorylation-dependent, anti-apoptotic mechanisms in Chronic Lymphocytic Leukemia (CLL). Inactivation of PP2A is due to the cooperative action of the phosphorylation of Y307 of its catalytic subunit by the aberrant cytosolic pool of the Src Family Kinase...
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Full title
Mitochondrial apoptosis is induced by Alkoxy phenyl-1-propanone derivatives through PP2A-mediated dephosphorylation of Bad and Foxo3A in CLL
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TN_cdi_proquest_miscellaneous_2125311483
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2125311483
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/s41375-018-0288-5
