Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice...
Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites
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Author / Creator
Liu, Ying , Cao, Zhongzheng , Wang, Yinan , Guo, Yu , Xu, Ping , Yuan, Pengfei , Liu, Zhiheng , He, Yuan and Wei, Wensheng
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Essential long noncoding RNAs are identified using Cas9 targeting of splice sites.
The functions of many long noncoding RNAs (lncRNAs) in the human genome remain unknown owing to the lack of scalable loss-of-function screening tools. We previously used pairs of CRISPR–Cas9 (refs.
1
,
2
,
3
) single guide RNAs (sgRNAs) for small...
Alternative Titles
Full title
Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites
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Record Identifier
TN_cdi_proquest_miscellaneous_2130058274
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2130058274
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.4283
