TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocyte...
TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Thymocyte development requires a complex orchestration of multiple transcription factors. Ablating either TCF-1 or HEB in CD4
+
CD8
+
thymocytes elicits similar developmental outcomes including increased proliferation, decreased survival, and fewer late
Tcra
rearrangements. Here, we provide a mechanistic explanation for these simi...
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Full title
TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes
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Record Identifier
TN_cdi_proquest_miscellaneous_2132735039
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2132735039
Other Identifiers
ISSN
1529-2908,1529-2916
E-ISSN
1529-2916
DOI
10.1038/s41590-018-0254-4
