The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions fo...
The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness
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Author / Creator
Melandri, Daisy , Zlatareva, Iva , Chaleil, Raphaël A. G. , Dart, Robin J. , Chancellor, Andrew , Nussbaumer, Oliver , Polyakova, Oxana , Roberts, Natalie A. , Wesch, Daniela , Kabelitz, Dieter , Irving, Peter M. , John, Susan , Mansour, Salah , Bates, Paul A. , Vantourout, Pierre and Hayday, Adrian C.
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
T lymphocytes expressing γδ T cell antigen receptors (TCRs) comprise evolutionarily conserved cells with paradoxical features. On the one hand, clonally expanded γδ T cells with unique specificities typify adaptive immunity. Conversely, large compartments of γδTCR
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intraepithelial lymphocytes (γδ IELs) exhibit limited TCR diversity and effec...
Alternative Titles
Full title
The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness
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TN_cdi_proquest_miscellaneous_2132735096
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2132735096
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-018-0253-5
