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Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus ven...

Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus ven...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2136068677

Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

About this item

Full title

Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

Publisher

New York: Nature Publishing Group US

Journal title

Nature medicine, 2019-01, Vol.25 (1), p.119-129

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Ibrutinib plus venetoclax is a highly effective combination in mantle cell lymphoma. However, strategies to enable the evaluation of therapeutic response are required. Our prospective analyses of patients within the AIM study revealed genomic profiles that clearly dichotomized responders and nonresponders. Mutations in
ATM
were present in mos...

Alternative Titles

Full title

Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2136068677

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2136068677

Other Identifiers

ISSN

1078-8956

E-ISSN

1546-170X

DOI

10.1038/s41591-018-0243-z

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