Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 positive-feedback...
Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 positive-feedback loop
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Author / Creator
Wang, Jun , Xu, Sen-Lin , Duan, Jiang-Jie , Yi, Liang , Guo, Yu-Feng , Shi, Yu , Li, Lin , Yang, Ze-Yu , Liao, Xue-Mei , Cai, Jiao , Zhang, Yan-Qi , Xiao, Hua-Liang , Yin, Li , Wu, Hao , Zhang, Jing-Na , Lv, Sheng-Qing , Yang, Qing-Kai , Yang, Xiao-Jun , Jiang, Tao , Zhang, Xia , Bian, Xiu-Wu and Yu, Shi-Cang
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Early invasive growth along specific anatomical structures, especially the white matter tract, is regarded as one of the main causes of poor therapeutic outcome of people with gliomas. We show that some glioma stem cells (GSCs) are preferentially located along white matter tracts, which exhibit a demyelinated phenotype, at the invasive frontier of...
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Full title
Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 positive-feedback loop
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Record Identifier
TN_cdi_proquest_miscellaneous_2158248031
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2158248031
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-018-0285-z
