Stochastic synaptic plasticity underlying compulsion in a model of addiction
Stochastic synaptic plasticity underlying compulsion in a model of addiction
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Activation of the mesolimbic dopamine system reinforces goal-directed behaviours. With repetitive stimulation—for example, by chronic drug abuse—the reinforcement may become compulsive and intake continues even in the face of major negative consequences. Here we gave mice the opportunity to optogenetically self-stimulate dopaminergic neurons and ob...
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Full title
Stochastic synaptic plasticity underlying compulsion in a model of addiction
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TN_cdi_proquest_miscellaneous_2159328357
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2159328357
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0789-4
