A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis
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Author / Creator
Kristjansson, Ragnar P. , Benonisdottir, Stefania , Davidsson, Olafur B. , Oddsson, Asmundur , Tragante, Vinicius , Sigurdsson, Jon K. , Stefansdottir, Lilja , Jonsson, Stefan , Jensson, Brynjar O. , Arthur, Joseph G. , Arnadottir, Gudny A. , Sulem, Gerald , Halldorsson, Bjarni V. , Gunnarsson, Bjarni , Halldorsson, Gisli H. , Stefansson, Olafur A. , Oskarsson, Gudjon R. , Deaton, Aimee M. , Olafsson, Isleifur , Eyjolfsson, Gudmundur I. , Sigurdardottir, Olof , Onundarson, Pall T. , Gislason, David , Gislason, Thorarinn , Ludviksson, Bjorn R. , Ludviksdottir, Dora , Olafsdottir, Thorunn A. , Rafnar, Thorunn , Masson, Gisli , Zink, Florian , Bjornsdottir, Gyda , Magnusson, Olafur Th , Bjornsdottir, Unnur S. , Thorleifsson, Gudmar , Norddahl, Gudmundur L. , Gudbjartsson, Daniel F. , Thorsteinsdottir, Unnur , Jonsdottir, Ingileif , Sulem, Patrick and Stefansson, Kari
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Nasal polyps (NP) are lesions on the nasal and paranasal sinus mucosa and are a risk factor for chronic rhinosinusitis (CRS). We performed genome-wide association studies on NP and CRS in Iceland and the UK (using UK Biobank data) with 4,366 NP cases, 5,608 CRS cases, and >700,000 controls. We found 10 markers associated with NP and 2 with CRS. We...
Alternative Titles
Full title
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis
Authors, Artists and Contributors
Author / Creator
Benonisdottir, Stefania
Davidsson, Olafur B.
Oddsson, Asmundur
Tragante, Vinicius
Sigurdsson, Jon K.
Stefansdottir, Lilja
Jonsson, Stefan
Jensson, Brynjar O.
Arthur, Joseph G.
Arnadottir, Gudny A.
Sulem, Gerald
Halldorsson, Bjarni V.
Gunnarsson, Bjarni
Halldorsson, Gisli H.
Stefansson, Olafur A.
Oskarsson, Gudjon R.
Deaton, Aimee M.
Olafsson, Isleifur
Eyjolfsson, Gudmundur I.
Sigurdardottir, Olof
Onundarson, Pall T.
Gislason, David
Gislason, Thorarinn
Ludviksson, Bjorn R.
Ludviksdottir, Dora
Olafsdottir, Thorunn A.
Rafnar, Thorunn
Masson, Gisli
Zink, Florian
Bjornsdottir, Gyda
Magnusson, Olafur Th
Bjornsdottir, Unnur S.
Thorleifsson, Gudmar
Norddahl, Gudmundur L.
Gudbjartsson, Daniel F.
Thorsteinsdottir, Unnur
Jonsdottir, Ingileif
Sulem, Patrick
Stefansson, Kari
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2179351420
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2179351420
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0314-6
