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A Hyperandrogenic Environment Causes Intrinsic Defects That Are Detrimental to Follicular Dynamics i...

A Hyperandrogenic Environment Causes Intrinsic Defects That Are Detrimental to Follicular Dynamics i...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2179372166

A Hyperandrogenic Environment Causes Intrinsic Defects That Are Detrimental to Follicular Dynamics in a PCOS Mouse Model

About this item

Full title

A Hyperandrogenic Environment Causes Intrinsic Defects That Are Detrimental to Follicular Dynamics in a PCOS Mouse Model

Publisher

United States: Oxford University Press

Journal title

Endocrinology (Philadelphia), 2019-03, Vol.160 (3), p.699-715

Language

English

Formats

Publication information

Publisher

United States: Oxford University Press

More information

Scope and Contents

Contents

Polycystic ovary syndrome (PCOS) is a common cause of female infertility. Hyperandrogenism is both a major symptom and key diagnostic trait of PCOS; however, the direct impact of this androgen excess on ovarian dynamics is unclear. By combining a DHT-induced PCOS mouse model with an ex vivo follicle culture system, we investigated the impact of hyp...

Alternative Titles

Full title

A Hyperandrogenic Environment Causes Intrinsic Defects That Are Detrimental to Follicular Dynamics in a PCOS Mouse Model

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2179372166

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2179372166

Other Identifiers

ISSN

1945-7170,0013-7227

E-ISSN

1945-7170

DOI

10.1210/en.2018-00966

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