Identification of inhibitors of the polo-box domain of polo-like kinase 1 from natural and semisynth...
Identification of inhibitors of the polo-box domain of polo-like kinase 1 from natural and semisynthetic compounds
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Publisher
New York: Springer US
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Language
English
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New York: Springer US
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Summary
PLK1 has an important role in the regulation of cell cycle and represents an important target for cancer treatment. This enzyme belongs to the Polo-like kinases family, which is characterized by a regulatory domain named Polo-box domain (PBD). Rather than regular kinase inhibitors, this domain provides high selectivity to PLK1. Here, we...
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Full title
Identification of inhibitors of the polo-box domain of polo-like kinase 1 from natural and semisynthetic compounds
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TN_cdi_proquest_miscellaneous_2193170044
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2193170044
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ISSN
0167-6997
E-ISSN
1573-0646
DOI
10.1007/s10637-019-00752-0
