Pathological Alterations of Tau in Alzheimer’s Disease and 3xTg-AD Mouse Brains
Pathological Alterations of Tau in Alzheimer’s Disease and 3xTg-AD Mouse Brains
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Publisher
New York: Springer US
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Language
English
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Publisher
New York: Springer US
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Contents
Microtubule-associated protein tau in Alzheimer’s disease (AD) brain is hyperphosphorylated, truncated, and aggregated into neurofibrillary tangles. Oligomeric and hyperphosphorylated tau (Oligo-tau) isolated from AD brain captures and templates normal tau into filaments both in vitro and in vivo; this prion-like activity is believed to be responsi...
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Full title
Pathological Alterations of Tau in Alzheimer’s Disease and 3xTg-AD Mouse Brains
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TN_cdi_proquest_miscellaneous_2229091863
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2229091863
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ISSN
0893-7648
E-ISSN
1559-1182
DOI
10.1007/s12035-019-1507-4
