Estimating In Vivo Fractional Contribution of OATP1B1 to Human Hepatic Active Uptake by Mechanistica...
Estimating In Vivo Fractional Contribution of OATP1B1 to Human Hepatic Active Uptake by Mechanistically Modeling Pharmacogenetic Data
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Publisher
Cham: Springer International Publishing
Journal title
Language
English
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Publisher
Cham: Springer International Publishing
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Scope and Contents
Contents
A reasonable estimate on the fractional contribution of transporters to total hepatic active uptake (
F
T
) is a critical factor in understanding and predicting human clearance, drug-drug interaction, and pharmacokinetic variability for hepatic transporter substrates.
F
T
values for organic-anion-transporting polypeptide (OATP) 1B...
Alternative Titles
Full title
Estimating In Vivo Fractional Contribution of OATP1B1 to Human Hepatic Active Uptake by Mechanistically Modeling Pharmacogenetic Data
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TN_cdi_proquest_miscellaneous_2231844904
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2231844904
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ISSN
1550-7416
E-ISSN
1550-7416
DOI
10.1208/s12248-019-0337-7
