MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Inhibition of the NLRP3 inflammasome is a promising strategy for the development of new treatments for inflammatory diseases. MCC950 is a potent and specific small-molecule inhibitor of the NLRP3 pathway, but its molecular target is not defined. Here, we show that MCC950 directly interacts with the Walker B motif within the NLRP3 NACHT domain, ther...
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MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
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TN_cdi_proquest_miscellaneous_2232016584
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2232016584
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-019-0277-7
