Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurre...
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial
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Author / Creator
Fangusaro, Jason, MD , Onar-Thomas, Arzu, Prof , Young Poussaint, Tina, Prof , Wu, Shengjie, MS , Ligon, Azra H, PhD , Lindeman, Neal, MD , Banerjee, Anuradha, MD , Packer, Roger J, Prof , Kilburn, Lindsay B, MD , Goldman, Stewart, Prof , Pollack, Ian F, Prof , Qaddoumi, Ibrahim, MD , Jakacki, Regina I, MD , Fisher, Paul G, Prof , Dhall, Girish, MD , Baxter, Patricia, MD , Kreissman, Susan G, Prof , Stewart, Clinton F, Prof , Jones, David T W, PhD , Pfister, Stefan M, MD , Vezina, Gilbert, MD , Stern, Jessica S, MD , Panigrahy, Ashok, Prof , Patay, Zoltan, Prof , Tamrazi, Benita, MD , Jones, Jeremy Y, MD , Haque, Sofia S, MD , Enterline, David S, MD , Cha, Soonmee, MD , Fisher, Michael J, Prof , Doyle, Laurence Austin, MD , Smith, Malcolm, MD , Dunkel, Ira J, Prof and Fouladi, Maryam, Prof
Publisher
England: Elsevier Ltd
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Language
English
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Publisher
England: Elsevier Ltd
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Contents
SummaryBackgroundPaediatric low-grade glioma is the most common CNS tumour of childhood. Although overall survival is good, disease often recurs. No single universally accepted treatment exists for these patients; however, standard cytotoxic chemotherapies are generally used. We aimed to assess the activity of selumetinib, a MEK1/2 inhibitor, in th...
Alternative Titles
Full title
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial
Authors, Artists and Contributors
Author / Creator
Onar-Thomas, Arzu, Prof
Young Poussaint, Tina, Prof
Wu, Shengjie, MS
Ligon, Azra H, PhD
Lindeman, Neal, MD
Banerjee, Anuradha, MD
Packer, Roger J, Prof
Kilburn, Lindsay B, MD
Goldman, Stewart, Prof
Pollack, Ian F, Prof
Qaddoumi, Ibrahim, MD
Jakacki, Regina I, MD
Fisher, Paul G, Prof
Dhall, Girish, MD
Baxter, Patricia, MD
Kreissman, Susan G, Prof
Stewart, Clinton F, Prof
Jones, David T W, PhD
Pfister, Stefan M, MD
Vezina, Gilbert, MD
Stern, Jessica S, MD
Panigrahy, Ashok, Prof
Patay, Zoltan, Prof
Tamrazi, Benita, MD
Jones, Jeremy Y, MD
Haque, Sofia S, MD
Enterline, David S, MD
Cha, Soonmee, MD
Fisher, Michael J, Prof
Doyle, Laurence Austin, MD
Smith, Malcolm, MD
Dunkel, Ira J, Prof
Fouladi, Maryam, Prof
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2233854795
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2233854795
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(19)30277-3
