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Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a carti...

Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a carti...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2235061427

Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model

About this item

Full title

Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model

Publisher

London: Nature Publishing Group UK

Journal title

Nature biomedical engineering, 2019-07, Vol.3 (7), p.545-557

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Owing to population aging, the social impact of osteoarthritis (OA)—the most common musculoskeletal disease—is expected to increase dramatically. Yet, therapy is still limited to palliative treatments or surgical intervention, and disease-modifying OA (DMOA) drugs are scarce, mainly because of the absence of relevant preclinical OA models. Therefor...

Alternative Titles

Full title

Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2235061427

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2235061427

Other Identifiers

ISSN

2157-846X

E-ISSN

2157-846X

DOI

10.1038/s41551-019-0406-3

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