TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
About this item
Full title
Author / Creator
Alfei, Francesca , Kanev, Kristiyan , Hofmann, Maike , Wu, Ming , Ghoneim, Hazem E. , Roelli, Patrick , Utzschneider, Daniel T. , von Hoesslin, Madlaina , Cullen, Jolie G. , Fan, Yiping , Eisenberg, Vasyl , Wohlleber, Dirk , Steiger, Katja , Merkler, Doron , Delorenzi, Mauro , Knolle, Percy A. , Cohen, Cyrille J. , Thimme, Robert , Youngblood, Benjamin and Zehn, Dietmar
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cytotoxic T cells are essential mediators of protective immunity to viral infection and malignant tumours and are a key target of immunotherapy approaches. However, prolonged exposure to cognate antigens often attenuates the effector capacity of T cells and limits their therapeutic potential
1
–
4
. This process, known as T cell exhaust...
Alternative Titles
Full title
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
Authors, Artists and Contributors
Author / Creator
Kanev, Kristiyan
Hofmann, Maike
Wu, Ming
Ghoneim, Hazem E.
Roelli, Patrick
Utzschneider, Daniel T.
von Hoesslin, Madlaina
Cullen, Jolie G.
Fan, Yiping
Eisenberg, Vasyl
Wohlleber, Dirk
Steiger, Katja
Merkler, Doron
Delorenzi, Mauro
Knolle, Percy A.
Cohen, Cyrille J.
Thimme, Robert
Youngblood, Benjamin
Zehn, Dietmar
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2242817715
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2242817715
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1326-9
