c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologie...
c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies
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Author / Creator
Bernink, Jochem H. , Ohne, Yoichiro , Teunissen, Marcel B. M. , Wang, Jingya , Wu, Jincheng , Krabbendam, Lisette , Guntermann, Christine , Volckmann, Richard , Koster, Jan , van Tol, Sophie , Ramirez, Ivan , Shrestha, Yashaswi , de Rie, Menno A. , Spits, Hergen , Romero Ros, Xavier and Humbles, Alison A.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Here we identify a group 2 innate lymphoid cell (ILC2) subpopulation that can convert into interleukin-17 (IL-17)-producing NKp44
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ILC3-like cells. c-Kit and CCR6 define this ILC2 subpopulation that exhibits ILC3 features, including RORγt, enabling the conversion into IL-17-producing cells in response to IL-1β and IL-23. We also report a rol...
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Full title
c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies
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Record Identifier
TN_cdi_proquest_miscellaneous_2251124304
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2251124304
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ISSN
1529-2908,1529-2916
E-ISSN
1529-2916
DOI
10.1038/s41590-019-0423-0
