Functional dissection of the Sox9–Kcnj2 locus identifies nonessential and instructive roles of TAD a...
Functional dissection of the Sox9–Kcnj2 locus identifies nonessential and instructive roles of TAD architecture
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
The genome is organized in three-dimensional units called topologically associating domains (TADs), through a process dependent on the cooperative action of cohesin and the DNA-binding factor CTCF. Genomic rearrangements of TADs have been shown to cause gene misexpression and disease, but genome-wide depletion of CTCF has no drastic effects on tran...
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Functional dissection of the Sox9–Kcnj2 locus identifies nonessential and instructive roles of TAD architecture
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TN_cdi_proquest_miscellaneous_2267027445
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2267027445
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-019-0466-z
