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Overexpression of Histone H3 Lysine 27 Trimethylation Is Associated with Aggressiveness and Dediffer...

Overexpression of Histone H3 Lysine 27 Trimethylation Is Associated with Aggressiveness and Dediffer...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2270007580

Overexpression of Histone H3 Lysine 27 Trimethylation Is Associated with Aggressiveness and Dedifferentiation of Thyroid Cancer

About this item

Full title

Overexpression of Histone H3 Lysine 27 Trimethylation Is Associated with Aggressiveness and Dedifferentiation of Thyroid Cancer

Publisher

New York: Springer US

Journal title

Endocrine pathology, 2019-12, Vol.30 (4), p.305-311

Language

English

Formats

Publication information

Publisher

New York: Springer US

More information

Scope and Contents

Contents

A variety of epigenetic dysregulations are observed in thyroid malignancies. EZH2, the catalytic subunit of polycomb repressive complex 2, is upregulated in advanced thyroid cancers. EZH2 can catalyze trimethylation of histone H3 at lysine 27 (H3K27me3) and contribute to transcriptional silencing of target genes. Here, we investigated the immunohis...

Alternative Titles

Full title

Overexpression of Histone H3 Lysine 27 Trimethylation Is Associated with Aggressiveness and Dedifferentiation of Thyroid Cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2270007580

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2270007580

Other Identifiers

ISSN

1046-3976

E-ISSN

1559-0097

DOI

10.1007/s12022-019-09586-1

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