CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
About this item
Full title
Author / Creator
Choi, Bryan D. , Yu, Xiaoling , Castano, Ana P. , Bouffard, Amanda A. , Schmidts, Andrea , Larson, Rebecca C. , Bailey, Stefanie R. , Boroughs, Angela C. , Frigault, Matthew J. , Leick, Mark B. , Scarfò, Irene , Cetrulo, Curtis L. , Demehri, Shadmehr , Nahed, Brian V. , Cahill, Daniel P. , Wakimoto, Hiroaki , Curry, William T. , Carter, Bob S. and Maus, Marcela V.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Chimeric antigen receptor (CAR)-T-cell therapy for solid tumors is limited due to heterogeneous target antigen expression and outgrowth of tumors lacking the antigen targeted by CAR-T cells directed against single antigens. Here, we developed a bicistronic construct to drive expression of a CAR specific for EGFRvIII, a glioblastoma-specific tumor a...
Alternative Titles
Full title
CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
Authors, Artists and Contributors
Author / Creator
Yu, Xiaoling
Castano, Ana P.
Bouffard, Amanda A.
Schmidts, Andrea
Larson, Rebecca C.
Bailey, Stefanie R.
Boroughs, Angela C.
Frigault, Matthew J.
Leick, Mark B.
Scarfò, Irene
Cetrulo, Curtis L.
Demehri, Shadmehr
Nahed, Brian V.
Cahill, Daniel P.
Wakimoto, Hiroaki
Curry, William T.
Carter, Bob S.
Maus, Marcela V.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2275274737
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2275274737
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/s41587-019-0192-1
