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Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism

Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2283105561

Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism

About this item

Full title

Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism

Publisher

London: Nature Publishing Group UK

Journal title

Molecular psychiatry, 2019-12, Vol.24 (12), p.1779-1786

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

We recently reported that naltrexone blocks antidepressant effects of ketamine in humans, indicating that antidepressant effects of ketamine require opioid receptor activation. However, it is unknown if opioid receptors are also involved in ketamine’s antisuicidality effects. Here, in a secondary analysis of our recent clinical trial, we test wheth...

Alternative Titles

Full title

Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2283105561

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2283105561

Other Identifiers

ISSN

1359-4184

E-ISSN

1476-5578

DOI

10.1038/s41380-019-0503-4

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