SARI attenuates colon inflammation by promoting STAT1 degradation in intestinal epithelial cells
SARI attenuates colon inflammation by promoting STAT1 degradation in intestinal epithelial cells
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Author / Creator
Dai, Lei , Liu, Yi , Cheng, Lin , Wang, Huiling , Lin, Yi , Shi, Gang , Dong, Zhexu , Li, Junshu , Fan, Ping , Wang, Qinnan , Su, Xiaolan , Zhang, Shuang , Yang, Yang , Hu, Xun , Huang, Wei , Zhou, Zongguang , Yu, Dechao , Probert, Christopher , Wei, Yuquan and Deng, Hongxin
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
SARI functions as a suppressor of colon cancer and predicts survival of colon cancer patients, but its role in regulating colitis has not been characterized. Here we show that
SARI
−/−
mice were highly susceptible to colitis, which was associated with enhanced macrophage infiltration and inflammatory cytokine production. Bone marrow recons...
Alternative Titles
Full title
SARI attenuates colon inflammation by promoting STAT1 degradation in intestinal epithelial cells
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Record Identifier
TN_cdi_proquest_miscellaneous_2283108885
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2283108885
Other Identifiers
ISSN
1933-0219
E-ISSN
1935-3456
DOI
10.1038/s41385-019-0178-9
