KNK437 restricts the growth and metastasis of colorectal cancer via targeting DNAJA1/CDC45 axis
KNK437 restricts the growth and metastasis of colorectal cancer via targeting DNAJA1/CDC45 axis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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As an inhibitor of heat shock proteins (HSPs), KNK437 has been reported to play an anti-tumor role in several cancers. But its therapeutic effect and mechanisms in colorectal cancer (CRC) remain unclear. Here, KNK437 sharply inhibited the level of DnaJ heat shock protein family (Hsp40) member A1 (DNAJA1), followed by DNAJB1, but had little effect o...
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KNK437 restricts the growth and metastasis of colorectal cancer via targeting DNAJA1/CDC45 axis
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TN_cdi_proquest_miscellaneous_2283996031
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2283996031
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ISSN
0950-9232,1476-5594
E-ISSN
1476-5594
DOI
10.1038/s41388-019-0978-0
