The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function
The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function
About this item
Full title
Author / Creator
Oberbeck, Nina , Pham, Victoria C. , Webster, Joshua D. , Reja, Rohit , Huang, Christine S. , Zhang, Yue , Roose-Girma, Merone , Warming, Søren , Li, Qingling , Birnberg, Andrew , Wong, Weng , Sandoval, Wendy , Kőműves, László G. , Yu, Kebing , Dugger, Debra L. , Maltzman, Allie , Newton, Kim and Dixit, Vishva M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The integrity of the mammalian epidermis depends on a balance of proliferation and differentiation in the resident population of stem cells
1
. The kinase RIPK4 and the transcription factor IRF6 are mutated in severe developmental syndromes in humans, and mice lacking these genes display epidermal hyperproliferation and soft-tissue fusions th...
Alternative Titles
Full title
The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2300599637
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2300599637
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1615-3
