Engineering of human brain organoids with a functional vascular-like system
Engineering of human brain organoids with a functional vascular-like system
About this item
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Author / Creator
Cakir, Bilal , Xiang, Yangfei , Tanaka, Yoshiaki , Kural, Mehmet H. , Parent, Maxime , Kang, Young-Jin , Chapeton, Kayley , Patterson, Benjamin , Yuan, Yifan , He, Chang-Shun , Raredon, Micha Sam B. , Dengelegi, Jake , Kim, Kun-Yong , Sun, Pingnan , Zhong, Mei , Lee, Sangho , Patra, Prabir , Hyder, Fahmeed , Niklason, Laura E. , Lee, Sang-Hun , Yoon, Young-Sup and Park, In-Hyun
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Human cortical organoids (hCOs), derived from human embryonic stem cells (hESCs), provide a platform to study human brain development and diseases in complex three-dimensional tissue. However, current hCOs lack microvasculature, resulting in limited oxygen and nutrient delivery to the inner-most parts of hCOs. We engineered hESCs to ectopically exp...
Alternative Titles
Full title
Engineering of human brain organoids with a functional vascular-like system
Authors, Artists and Contributors
Author / Creator
Xiang, Yangfei
Tanaka, Yoshiaki
Kural, Mehmet H.
Parent, Maxime
Kang, Young-Jin
Chapeton, Kayley
Patterson, Benjamin
Yuan, Yifan
He, Chang-Shun
Raredon, Micha Sam B.
Dengelegi, Jake
Kim, Kun-Yong
Sun, Pingnan
Zhong, Mei
Lee, Sangho
Patra, Prabir
Hyder, Fahmeed
Niklason, Laura E.
Lee, Sang-Hun
Yoon, Young-Sup
Park, In-Hyun
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2302482135
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2302482135
Other Identifiers
ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/s41592-019-0586-5
