Prolyl Hydroxylase Inhibition Mitigates Pouchitis
Prolyl Hydroxylase Inhibition Mitigates Pouchitis
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Publisher
US: Oxford University Press
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Language
English
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Publication information
Publisher
US: Oxford University Press
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Scope and Contents
Contents
We demonstrate that PHD1 is overexpressed in pouchitis in patients with ulcerative colitis and correlates with disease activity. PHD small-molecule inhibition mitigates pouchitis in a preclinical rodent IPAA model, thus establishing a strong therapeutic rationale for targeting PHD1 in pouchitis.AbstractBackgroundPouchitis is the most common long-te...
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Full title
Prolyl Hydroxylase Inhibition Mitigates Pouchitis
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Record Identifier
TN_cdi_proquest_miscellaneous_2306495041
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2306495041
Other Identifiers
ISSN
1078-0998
E-ISSN
1536-4844
DOI
10.1093/ibd/izz218
