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CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells v...

CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells v...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2316783674

CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling

About this item

Full title

CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling

Publisher

New York: Elsevier Inc

Journal title

Laboratory investigation, 2020-04, Vol.100 (4), p.619-629

Language

English

Formats

Publication information

Publisher

New York: Elsevier Inc

More information

Scope and Contents

Contents

Tumor-associated macrophages (TAMs) constitute a large population of glioblastoma and facilitate tumor growth and invasion of tumor cells, but the underlying mechanism remains undefined. In this study, we demonstrate that chemokine (C-C motif) ligand 8 (CCL8) is highly expressed by TAMs and contributes to pseudopodia formation by GBM cells. The pre...

Alternative Titles

Full title

CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2316783674

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2316783674

Other Identifiers

ISSN

0023-6837

E-ISSN

1530-0307

DOI

10.1038/s41374-019-0345-3

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