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Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fi...

Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2318733039

Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

About this item

Full title

Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

Publisher

London: Nature Publishing Group UK

Journal title

Nature microbiology, 2020-01, Vol.5 (1), p.27-33

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein—a mutation that confers reduced susceptibility to baloxavir marboxil—from patients before and after treatment with baloxavir marboxil in Japan. These variants showed replicative abilities and p...

Alternative Titles

Full title

Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2318733039

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2318733039

Other Identifiers

ISSN

2058-5276

E-ISSN

2058-5276

DOI

10.1038/s41564-019-0609-0

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