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CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negativ...

CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negativ...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2319487871

CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling

About this item

Full title

CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling

Publisher

London: Nature Publishing Group UK

Journal title

Leukemia, 2020-05, Vol.34 (5), p.1305-1314

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Recurrent oncogenic mutations of MyD88 have been identified in a variety of lymphoid malignancies. Gain-of-function mutations of MyD88 constitutively activate downstream NF-κB signaling pathways, resulting in increased cellular proliferation and survival. However, whether MyD88 activity can be aberrantly regulated in MyD88-wild-type lymphoid malign...

Alternative Titles

Full title

CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2319487871

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2319487871

Other Identifiers

ISSN

0887-6924

E-ISSN

1476-5551

DOI

10.1038/s41375-019-0661-z

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