Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation
Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation
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Author / Creator
Song, Jinghui , Zhuang, Yuan , Zhu, Chenxu , Meng, Haowei , Lu, Bo , Xie, Bingteng , Peng, Jinying , Li, Mo and Yi, Chengqi
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Pseudouridine synthases (PUSs) are responsible for installation of pseudouridine (Ψ) modification in RNA. However, the activity and function of the PUS enzymes remain largely unexplored. Here we focus on human PUS10 and find that it co-expresses with the microprocessor (DROSHA–DGCR8 complex). Depletion of PUS10 results in a marked reduction of the...
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Full title
Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation
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Record Identifier
TN_cdi_proquest_miscellaneous_2323481239
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2323481239
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-019-0420-5
