Role of cyclin-dependent kinase 2 in the progression of mouse juvenile cystic kidney disease
Role of cyclin-dependent kinase 2 in the progression of mouse juvenile cystic kidney disease
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Publisher
New York: Elsevier Inc
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Language
English
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Publisher
New York: Elsevier Inc
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Contents
A hallmark of polycystic kidney diseases (PKDs) is aberrant proliferation, which leads to the formation and growth of renal cysts. Proliferation is mediated by cyclin-dependent kinases (Cdks), and the administration of roscovitine (a pan-Cdk inhibitor) attenuates renal cystic disease in juvenile cystic kidney (jck) mice. Cdk2 is a key regulator of...
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Full title
Role of cyclin-dependent kinase 2 in the progression of mouse juvenile cystic kidney disease
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TN_cdi_proquest_miscellaneous_2335169050
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2335169050
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ISSN
0023-6837
E-ISSN
1530-0307
DOI
10.1038/s41374-019-0360-4
