Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization
Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
The RAS–RAF–MEK–ERK signaling axis is frequently activated in human cancers. Physiological concentrations of ATP prevent formation of RAF kinase-domain (RAF
KD
) dimers that are critical for activity. Here we present a 2.9-Å-resolution crystal structure of human BRAF
KD
in complex with MEK and the ATP analog AMP-PCP, revealing interacti...
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Full title
Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization
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TN_cdi_proquest_miscellaneous_2347507335
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2347507335
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-019-0365-0
