A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-c...
A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Approaches to increase the activity of chimeric antigen receptor (CAR)-T cells against solid tumors may also increase the risk of toxicity and other side effects. To improve the safety of CAR-T-cell therapy, we computationally designed a chemically disruptable heterodimer (CDH) based on the binding of two human proteins. The CDH self-assembles, can...
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Full title
A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy
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TN_cdi_proquest_miscellaneous_2350904278
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2350904278
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ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/s41587-019-0403-9
