The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen...
The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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GPR81 is a G-protein-coupled receptor for lactate, which is upregulated in breast cancer and plays an autocrine role to promote tumor growth by tumor cell-derived lactate. Here we asked whether lactate has any paracrine role via activation of GPR81 in cells present in tumor microenvironment to help tumor growth. First, we showed that deletion of Gp...
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Full title
The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment
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TN_cdi_proquest_miscellaneous_2358569738
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2358569738
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-020-1216-5
