Structural basis of ligand recognition and self-activation of orphan GPR52
Structural basis of ligand recognition and self-activation of orphan GPR52
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Author / Creator
Lin, Xi , Li, Mingyue , Wang, Niandong , Wu, Yiran , Luo, Zhipu , Guo, Shimeng , Han, Gye-Won , Li, Shaobai , Yue, Yang , Wei, Xiaohu , Xie, Xin , Chen, Yong , Zhao, Suwen , Wu, Jian , Lei, Ming and Xu, Fei
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
GPR52 is a class-A orphan G-protein-coupled receptor that is highly expressed in the brain and represents a promising therapeutic target for the treatment of Huntington’s disease and several psychiatric disorders
1
,
2
. Pathological malfunction of GPR52 signalling occurs primarily through the heterotrimeric G
s
protein
2
,...
Alternative Titles
Full title
Structural basis of ligand recognition and self-activation of orphan GPR52
Authors, Artists and Contributors
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Record Identifier
TN_cdi_proquest_miscellaneous_2359399456
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2359399456
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2019-0
