EGFR activation-induced decreases in claudin1 promote MUC5AC expression and exacerbate asthma in mic...
EGFR activation-induced decreases in claudin1 promote MUC5AC expression and exacerbate asthma in mice
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Author / Creator
Jia, Zhirong , Bao, Kaifan , Wei, Pan , Yu, Xuerui , Zhang, Yuheng , Wang, Xiaotong , Wang, Xiaoyu , Yao, Lu , Li, Lianqu , Wu, Peng , Yuan, Weiyuan , Wang, Siqi , Zheng, Jie , Hua, Yongqing and Hong, Min
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Claudin1 plays a critical role in maintaining the epithelial barrier, and mucus hypersecretion induced by epidermal growth factor receptor (EGFR) activation is a pivotal pathological feature of asthma. The relationship between claudin1 expression and mucus hypersecretion and EGFR activation is still poorly understood. In this report, we showed that...
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Full title
EGFR activation-induced decreases in claudin1 promote MUC5AC expression and exacerbate asthma in mice
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TN_cdi_proquest_miscellaneous_2371855325
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2371855325
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ISSN
1933-0219
E-ISSN
1935-3456
DOI
10.1038/s41385-020-0272-z
