Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection...
Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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We demonstrate single-particle charge detection mass spectrometry on an Orbitrap for the analysis of megadalton biomolecular assemblies. We establish that the signal amplitudes of individual ions scale linearly with their charge, which can be used to resolve mixed ion populations, determine charge states and thus also determine the masses of indivi...
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Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry
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TN_cdi_proquest_miscellaneous_2375905007
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2375905007
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ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/s41592-020-0770-7
