BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cance...
BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial
About this item
Full title
Author / Creator
Bockorny, Bruno , Semenisty, Valerya , Macarulla, Teresa , Borazanci, Erkut , Wolpin, Brian M. , Stemmer, Salomon M. , Golan, Talia , Geva, Ravit , Borad, Mitesh J. , Pedersen, Katrina S. , Park, Joon Oh , Ramirez, Robert A. , Abad, David G. , Feliu, Jaime , Muñoz, Andres , Ponz-Sarvise, Mariano , Peled, Amnon , Lustig, Tzipora M. , Bohana-Kashtan, Osnat , Shaw, Stephen M. , Sorani, Ella , Chaney, Marya , Kadosh, Shaul , Vainstein Haras, Abi , Von Hoff, Daniel D. and Hidalgo, Manuel
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Programmed cell death 1 (PD-1) inhibitors have limited effect in pancreatic ductal adenocarcinoma (PDAC), underscoring the need to co-target alternative pathways. CXC chemokine receptor 4 (CXCR4) blockade promotes T cell tumor infiltration and is synergistic with anti-PD-1 therapy in PDAC mouse models. We conducted a phase IIa, open-label, two-coho...
Alternative Titles
Full title
BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial
Authors, Artists and Contributors
Author / Creator
Semenisty, Valerya
Macarulla, Teresa
Borazanci, Erkut
Wolpin, Brian M.
Stemmer, Salomon M.
Golan, Talia
Geva, Ravit
Borad, Mitesh J.
Pedersen, Katrina S.
Park, Joon Oh
Ramirez, Robert A.
Abad, David G.
Feliu, Jaime
Muñoz, Andres
Ponz-Sarvise, Mariano
Peled, Amnon
Lustig, Tzipora M.
Bohana-Kashtan, Osnat
Shaw, Stephen M.
Sorani, Ella
Chaney, Marya
Kadosh, Shaul
Vainstein Haras, Abi
Von Hoff, Daniel D.
Hidalgo, Manuel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2406949682
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2406949682
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X
DOI
10.1038/s41591-020-0880-x
