Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer...
Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer vulnerability to ATR inhibition
About this item
Full title
Author / Creator
Shu, Zhen , Li, Zhen , Huang, Huanhuan , Chen, Yan , Fan, Jun , Yu, Li , Wu, Zhihui , Tian, Ling , Qi, Qi , Peng, Shuang , Wei, Changyong , Xie, Zhongqiu , Li, Xiaobo , Feng, Qi , Sheng, Hao , Li, Guangqiang , Wei, Dongping , Shan, Changliang and Chen, Guo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Ribonucleotide reductase (RNR) catalyzes the rate-limiting step of de novo synthesis of deoxyribonucleotide triphosphates (dNTPs) building blocks for DNA synthesis, and is a well-recognized target for cancer therapy. RNR is a heterotetramer consisting of two large RRM1 subunits and two small RRM2 subunits. RNR activity is greatly stimulated by tran...
Alternative Titles
Full title
Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer vulnerability to ATR inhibition
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2427525089
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2427525089
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-020-01403-y
