Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy
Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy
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Author / Creator
Yamazaki, Takahiro , Kirchmair, Alexander , Sato, Ai , Buqué, Aitziber , Rybstein, Marissa , Petroni, Giulia , Bloy, Norma , Finotello, Francesca , Stafford, Lena , Navarro Manzano, Esther , Ayala de la Peña, Francisco , García-Martínez, Elena , Formenti, Silvia C. , Trajanoski, Zlatko and Galluzzi, Lorenzo
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Autophagy supports both cellular and organismal homeostasis. However, whether autophagy should be inhibited or activated for cancer therapy remains unclear. Deletion of essential autophagy genes increased the sensitivity of mouse mammary carcinoma cells to radiation therapy in vitro and in vivo (in immunocompetent syngeneic hosts). Autophagy-defici...
Alternative Titles
Full title
Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2430370515
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2430370515
Other Identifiers
ISSN
1529-2908,1529-2916
E-ISSN
1529-2916
DOI
10.1038/s41590-020-0751-0
