TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons
TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons
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Author / Creator
Nagano, Seiichi , Jinno, Junki , Abdelhamid, Rehab F. , Jin, Yinshi , Shibata, Megumi , Watanabe, Shohei , Hirokawa, Sachiko , Nishizawa, Masatoyo , Sakimura, Kenji , Onodera, Osamu , Okada, Hironori , Okada, Takashi , Saito, Yuko , Takahashi-Fujigasaki, Junko , Murayama, Shigeo , Wakatsuki, Shuji , Mochizuki, Hideki and Araki, Toshiyuki
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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More information
Scope and Contents
Contents
Mislocalization and abnormal deposition of TDP-43 into the cytoplasm (TDP-43 proteinopathy) is a hallmark in neurons of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). However, the pathogenic mechanism of the diseases linked to TDP-43 is largely unknown. We hypothesized that the failure of mRNA transport to neurona...
Alternative Titles
Full title
TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons
Authors, Artists and Contributors
Author / Creator
Jinno, Junki
Abdelhamid, Rehab F.
Jin, Yinshi
Shibata, Megumi
Watanabe, Shohei
Hirokawa, Sachiko
Nishizawa, Masatoyo
Sakimura, Kenji
Onodera, Osamu
Okada, Hironori
Okada, Takashi
Saito, Yuko
Takahashi-Fujigasaki, Junko
Murayama, Shigeo
Wakatsuki, Shuji
Mochizuki, Hideki
Araki, Toshiyuki
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2434753341
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2434753341
Other Identifiers
ISSN
0001-6322,1432-0533
E-ISSN
1432-0533
DOI
10.1007/s00401-020-02205-y
