CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer
CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer
About this item
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Author / Creator
Huang, Jin , Chen, Pan , Liu, Ke , Liu, Jiao , Zhou, Borong , Wu, Runliu , Peng, Qiu , Liu, Ze-Xian , Li, Changfeng , Kroemer, Guido , Lotze, Michael , Zeh, Herbert , Kang, Rui and Tang, Daolin
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title
Language
English
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Publication information
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Subjects
More information
Scope and Contents
Contents
ObjectiveAdaptive immune resistance mediated by the cytokine interferon gamma (IFNG) still constitutes a major problem in cancer immunotherapy. We develop strategies for overcoming IFNG-mediated adaptive immune resistance in pancreatic ductal adenocarcinoma cancer (PDAC).DesignWe screened 429 kinase inhibitors for blocking IFNG-induced immune check...
Alternative Titles
Full title
CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2436397796
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2436397796
Other Identifiers
ISSN
0017-5749
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2019-320441
