Expression of S100 proteins is associated with HBV intrauterine transmission
Expression of S100 proteins is associated with HBV intrauterine transmission
About this item
Full title
Author / Creator
Zhao, Peng , Wen, Jie , Qian, Linyan , Zhu, Xiaojun , Wang, Hong and Bai, Xiaoxia
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Purpose
The mechanisms underlying HBV intrauterine transmission remain unknown. In this study, we explored the mechanism of HBV intrauterine transmission by iTRAQ proteomics analysis.
Methods
iTRAQ technology was applied to perform comparative proteomics studies on six HBV
+/+
neonates and six HBV
+/−
neonates whose mothers and fathers were HBsAg positive and paternal HBsAg negative, respectively. The data obtained from the mass spectrometer were analyzed using MASCOT (
https://matrixscience.com
) to qualitatively and quantitatively compare the differentially expressed proteins in the two groups. Gene Ontology and KEGG pathway analyses were performed to analyze the differentially expressed proteins. The expressions of HBV intrauterine transmission-related proteins in serum samples and corresponding placental tissues were further ve...
Alternative Titles
Full title
Expression of S100 proteins is associated with HBV intrauterine transmission
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2438685018
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2438685018
Other Identifiers
ISSN
0932-0067
E-ISSN
1432-0711
DOI
10.1007/s00404-020-05753-6
