Rational design of the carbonyl reductase EbSDR8 for efficient biosynthesis of enantiopure (R)-3-chl...
Rational design of the carbonyl reductase EbSDR8 for efficient biosynthesis of enantiopure (R)-3-chloro-1-phenyl-1-propanol
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Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Scope and Contents
Contents
(
R
)-3-Chloro-1-phenyl-1-propanol ((
R
)-CPPO) is an important chiral intermediate for antidepressants. For its efficient biosynthesis, the carbonyl reductase EbSDR8 was engineered to asymmetrically reduce the unnatural substrate 3-chloro-1-phenyl-1-propanone (3-CPP) at high concentrations. Molecular docking and molecular dynamics simu...
Alternative Titles
Full title
Rational design of the carbonyl reductase EbSDR8 for efficient biosynthesis of enantiopure (R)-3-chloro-1-phenyl-1-propanol
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Author / Creator
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Record Identifier
TN_cdi_proquest_miscellaneous_2444605909
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2444605909
Other Identifiers
ISSN
0175-7598
E-ISSN
1432-0614
DOI
10.1007/s00253-020-10904-5
